Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy

Cells. 2019 Oct 14;8(10):1248. doi: 10.3390/cells8101248.

Abstract

Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior, promoting or inhibiting proliferation, apoptosis and sensitivity to therapies. In this review, we will recapitulate the role of various shuttling components in Chronic Myeloid Leukemia and we will provide insights on the potential role of shuttling proteins as therapeutic targets.

Keywords: BCR-ABL; PTEN; chronic myeloid leukemia; miRNA; nuclear-cytoplasmic shuttling; p53.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • Cytosol / metabolism
  • Exportin 1 Protein
  • Humans
  • Hydrazines / pharmacology
  • Karyopherins / metabolism
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / physiopathology*
  • Nuclear Export Signals / physiology
  • Nuclear Localization Signals / metabolism
  • Nuclear Localization Signals / physiology
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Triazoles / pharmacology

Substances

  • Hydrazines
  • Karyopherins
  • Nuclear Export Signals
  • Nuclear Localization Signals
  • Receptors, Cytoplasmic and Nuclear
  • Triazoles
  • selinexor