Cu(II)-Catalyzed Homocouplings of (Hetero)Arylboronic Acids with the Assistance of 2- O-Methyl-d-Glucopyranose

Molecules. 2019 Oct 12;24(20):3678. doi: 10.3390/molecules24203678.

Abstract

This is the first report of a natural ligand improving the copper-catalyzed homocouplings of (hetero)arylboronic acids. Various important synthetic biaryl intermediates in organic synthesis could be assembled via this method. To gain insight into this reaction, in situ React IR technology was used to confirm the effectivity of this catalyst system. This protocol could provide important biaryl compounds in high yields within a short time.

Keywords: (hetero)arylboronic acids; 2-O-methyl-d-glucopyranose; copper catalyst; homocoupling.

MeSH terms

  • Boronic Acids / chemistry*
  • Catalysis*
  • Copper / chemistry*
  • Ligands
  • Molecular Structure

Substances

  • Boronic Acids
  • Ligands
  • Copper