Objective: To analyze and summarize the clinical-pathological features of dermatosis papulosa nigra of Han Chinese people. Methods: We collected 71 cases of dermatosis papulosa nigra in the Third people's Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University of Department of Dermatology from January 2010 to January 2019 which were confirmed clinically and pathologically. The clinical and histopathological data of all patients were analyzed and summarized, and relevant literature were reviewed. Results: Among the 71 patients, 51 were female and 25 were male, their average age was (44±13) years, the average age of onset was (39±14) years, and the average time of diagnosis was (65±51) months. The lesions were multiple dark brown papules with smooth surface, and mostly distributed in the chest and abdomen, 46 cases (64.8%), followed by the back and neck. The mean diameter of the lesions was (1.76±0.99) mm. Meanwhile, the initial onset of pruritus was observed in 15 patients. The pathological features of all lesions were similar to seborrheic keratosis. According to pathological classification, there were 49 (69.0%) cases of the acanthotic type, 11(15.5%) cases of the hyperkeratotic type, 6 (8.5%) cases of spiroid type, 4 (5.6%) cases of irritated type, and 1 (1.4%) case of clonal type. Epidermal pigmentation and/or dermal papillary pigmented granules were observed in 56 cases (78.9%), of which 46 cases (64.8%) had basal layer pigmentation. In addition, inflammatory cell infiltration was found in the superficial dermis of lesions of 10 patients (14.1%) with symptom of itching. Conclusion: Dermatosis papulosa nigra of Han Chinese people has some unique clinical and pathological features.
目的： 分析总结我国汉族人黑色丘疹性皮病的临床和组织病理学特征。 方法： 收集杭州市第三人民医院皮肤科门诊从2010年1月至2019年1月经临床和病理学确诊的黑色丘疹性皮病71例，对所有患者的临床及组织病理学资料进行分析总结。 结果： 71例患者中女51例，男25例，年龄（44±13）岁，发病年龄（39±14）岁，确诊时间（65±51）个月；皮损为多发性深褐色扁平丘疹，表面光滑；皮损多分布于胸腹部，共46例（64.8%），其次为背部及颈部；皮疹平均直径为（1.76±0.99）mm；15例患者初始发病时感皮疹瘙痒。所有患者的皮损病理学特征类似于脂溢性角化病，按照病理学分型：棘层肥厚型49例（69.0%），角化过度型11例（15.5%），塔尖样型6例（8.5%），刺激型4例（5.6%），克隆型1例（1.4%）；56例（78.9%）可见表皮色素沉着和（或）真皮乳头色素颗粒，其中仅基底层色素沉着46例（64.8%）；10例（14.1%）瘙痒性皮损真皮浅层均可见炎症细胞浸润。 结论： 我国汉族人黑色丘疹性皮病具有一些独特的临床与病理学特征。.
Keywords: Dermatosis papulosa nigra; Han Chinese People; Seborrheic keratosis; Verruca planae.