m6A promotes R-loop formation to facilitate transcription termination

Xin Yang; Qian-Lan Liu; Wei Xu; Yi-Chang Zhang; Ying Yang; Lin-Fang Ju; Jing Chen; Yu-Sheng Chen; Kuan Li; Jie Ren; Qianwen Sun; Yun-Gui Yang

doi:10.1038/s41422-019-0235-7

m⁶A promotes R-loop formation to facilitate transcription termination

Cell Res. 2019 Dec;29(12):1035-1038. doi: 10.1038/s41422-019-0235-7. Epub 2019 Oct 12.

Authors

Xin Yang^#¹, Qian-Lan Liu^#^{1

2}, Wei Xu^#³, Yi-Chang Zhang^#^{1

2}, Ying Yang^{1

2

4}, Lin-Fang Ju^{1

2}, Jing Chen^{1

2}, Yu-Sheng Chen^{1

2}, Kuan Li³, Jie Ren^{5

6

7

8}, Qianwen Sun⁹, Yun-Gui Yang^{10

11

12

13}

Affiliations

¹ CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, School of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
⁵ CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, School of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. renjie@big.ac.cn.
⁶ University of Chinese Academy of Sciences, Beijing, 100049, China. renjie@big.ac.cn.
⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. renjie@big.ac.cn.
⁸ Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 101408, China. renjie@big.ac.cn.
⁹ Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China. sunqianwen@mail.tsinghua.edu.cn.
¹⁰ CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, School of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. ygyang@big.ac.cn.
¹¹ University of Chinese Academy of Sciences, Beijing, 100049, China. ygyang@big.ac.cn.
¹² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ygyang@big.ac.cn.
¹³ Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 101408, China. ygyang@big.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Adenosine / analogs & derivatives*
Adenosine / physiology
HEK293 Cells
HeLa Cells
Humans
Methyltransferases / metabolism
R-Loop Structures*
Transcription Termination, Genetic*

Substances

N-methyladenosine
Methyltransferases
Adenosine

Publication types

MeSH terms

Substances

Grants and funding