Design-augmented (DA) biologics: BMP chimeras for bone and cartilage regeneration

Osteoarthritis Cartilage. 2020 Feb;28(2):123-125. doi: 10.1016/j.joca.2019.09.004. Epub 2019 Oct 10.

Authors

P C Gray¹, S Choe²

Affiliations

¹ Qualcomm Institute, University of California San Diego, Atkinson Hall - Fifth Floor, 9500 Gilman Drive #0436, La Jolla, CA 92093-0436, USA. Electronic address: pgray816@gmail.com.
² Qualcomm Institute, University of California San Diego, Atkinson Hall - Fifth Floor, 9500 Gilman Drive #0436, La Jolla, CA 92093-0436, USA; Protein Engineering Laboratory, Joint Center for Biosciences, Songdo Smart Valley, Yeonsu-gu, Incheon, 406-840, USA. Electronic address: schoe@ucsd.edu.

PMID: 31606451
DOI: 10.1016/j.joca.2019.09.004

No abstract available

Publication types

Editorial

MeSH terms

Activins / genetics
Activins / pharmacology
Biological Products*
Bone Morphogenetic Protein 2 / genetics
Bone Morphogenetic Protein 2 / pharmacology
Bone Morphogenetic Protein 6 / genetics
Bone Morphogenetic Protein 6 / pharmacology
Bone Morphogenetic Protein 7 / genetics
Bone Morphogenetic Protein 7 / pharmacology
Bone Morphogenetic Proteins / genetics
Bone Morphogenetic Proteins / pharmacology
Bone Regeneration / drug effects*
Cartilage / drug effects*
Drug Design*
Humans
Recombinant Fusion Proteins / pharmacology*
Regeneration / drug effects

Substances

AB204
Biological Products
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 6
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins
Recombinant Fusion Proteins
activin A
Activins