Toward peste des petits virus (PPRV) eradication: Diagnostic approaches, novel vaccines, and control strategies

Virus Res. 2019 Dec:274:197774. doi: 10.1016/j.virusres.2019.197774. Epub 2019 Oct 10.

Abstract

Peste des petits ruminants (PPR) is an acute transboundary infectious viral disease affecting domestic and wild small ruminants' species besides camels reared in Africa, Asia and the Middle East. The virus is a serious paramount challenge to the sustainable agriculture advancement in the developing world. The disease outbreak was also detected for the first time in the European Union namely in Bulgaria at 2018. Therefore, the disease has lately been aimed for eradication with the purpose of worldwide clearance by 2030. Radically, the vaccines needed for effectively accomplishing this aim are presently convenient; however, the availableness of innovative modern vaccines to fulfill the desideratum for Differentiating between Infected and Vaccinated Animals (DIVA) may mitigate time spent and financial disbursement of serological monitoring and surveillance in the advanced levels for any disease obliteration campaign. We here highlight what is at the present time well-known about the virus and the different available diagnostic tools. Further, we interject on current updates and insights on several novel vaccines and on the possible current and prospective strategies to be applied for disease control.

Keywords: DIVA; Live attenuated vaccine; Live vector vaccine; PPR; PPR control; PPR diagnosis; PPRV; Subunit vaccines.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Laboratory Techniques / veterinary
  • Disease Eradication*
  • Genome, Viral
  • Peste-des-Petits-Ruminants / diagnosis*
  • Peste-des-Petits-Ruminants / epidemiology
  • Peste-des-Petits-Ruminants / prevention & control*
  • Peste-des-petits-ruminants virus* / classification
  • Peste-des-petits-ruminants virus* / immunology
  • Peste-des-petits-ruminants virus* / isolation & purification
  • Peste-des-petits-ruminants virus* / physiology
  • Vaccination / veterinary
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / classification
  • Viral Vaccines / administration & dosage
  • Viral Vaccines / classification

Substances

  • Vaccines, Attenuated
  • Viral Vaccines