Pathophysiology of Tumor Cell Release into the Circulation and Characterization of CTC

Tilman Todenhöfer; Klaus Pantel; Arnulf Stenzl; Stefan Werner

doi:10.1007/978-3-030-26439-0_1

Pathophysiology of Tumor Cell Release into the Circulation and Characterization of CTC

Recent Results Cancer Res. 2020:215:3-24. doi: 10.1007/978-3-030-26439-0_1.

Authors

Tilman Todenhöfer¹, Klaus Pantel², Arnulf Stenzl¹, Stefan Werner³

Affiliations

¹ Department of Urology, Eberhard-Karls-University, Tuebingen, Germany.
² Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. pantel@uke.de.
³ Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

PMID: 31605221
DOI: 10.1007/978-3-030-26439-0_1

Abstract

The traditional model of metastatic progression postulates that the ability to form distant metastases is driven by random mutations in cells of the primary tumor.

MeSH terms

Disease Progression
Humans
Mutation
Neoplasm Metastasis / genetics*
Neoplastic Cells, Circulating / metabolism*
Neoplastic Cells, Circulating / pathology*