Non-motor correlates of wrist-worn wearable sensor use in Parkinson's disease: an exploratory analysis

Daniel J van Wamelen; Shweta Hota; Aleksandra Podlewska; Valentina Leta; Dhaval Trivedi; Alexandra Rizos; Miriam Parry; K Ray Chaudhuri

doi:10.1038/s41531-019-0094-4

Non-motor correlates of wrist-worn wearable sensor use in Parkinson's disease: an exploratory analysis

NPJ Parkinsons Dis. 2019 Oct 2:5:22. doi: 10.1038/s41531-019-0094-4. eCollection 2019.

Authors

Daniel J van Wamelen^{1

2

3}, Shweta Hota¹, Aleksandra Podlewska^{1

2

4}, Valentina Leta^{1

2

5}, Dhaval Trivedi^{1

2}, Alexandra Rizos², Miriam Parry^{1

2}, K Ray Chaudhuri^{1

2}

Affiliations

¹ 1King's College London, Department of neurosciences, Institute of Psychiatry, Psychology & Neuroscience, De Crespigny Park, London, SE5 8AF UK.
² 2Parkinson Foundation Centre of Excellence, King's College Hospital, Denmark Hill, London, SE5 9RS UK.
³ 3Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
⁴ 4School of Psychology, University of Kent, Canterbury, CT2 7PM Kent, UK.
⁵ University of Milan, L. Sacco Hospital, Milan, Italy.

Abstract

Wearable sensors are becoming increasingly more available in Parkinson's disease and are used to measure motor function. Whether non-motor symptoms (NMS) can also be measured with these wearable sensors remains unclear. We therefore performed a retrospective, exploratory, analysis of 108 patients with a diagnosis of idiopathic Parkinson's disease enroled in the Non-motor Longitudinal International Study (UKCRN No. 10084) at King's College Hospital, London, to determine the association between the range and nature of NMS and an accelerometer-based outcome measure of bradykinesia (BKS) and dyskinesia (DKS). NMS were assessed by the validated NMS Scale, and included, e.g., cognition, mood and sleep, and gastrointestinal, urinary and sexual problems. Multiple linear regression modelling was used to identify NMS associated with BKS and DKS. We found that BKS was associated with domains 6 (gastrointestinal tract; p = 0.006) and 8 (sexual function; p = 0.003) of the NMS scale. DKS was associated with domains 3 (mood/cognition; p = 0.016), 4 (perceptual problems; p = 0.025), 6 (gastrointestinal tract; p = 0.029) and 9 (miscellaneous, p = 0.003). In the separate domains, constipation was significantly associated with BKS. Delusions, dysphagia, hyposmia, weight change and hyperhidrosis were identified as significantly associated with DKS. None of the NMSS domains were associated with disease duration (p ≥ 0.08). In conclusion, measures of BKS and DKS were mainly associated with gastrointestinal problems, independent of disease duration, showing the potential for wearable devices to pick up on these symptoms. These exploratory results deserve further exploration, and more research on this topic in the form of comprehensive large-scale studies is needed.

Keywords: Outcomes research; Parkinson's disease.