The correlation between feeding intolerance and poor prognosis of patients with severe neurological conditions: a case-control study

Expert Rev Neurother. 2019 Dec;19(12):1265-1270. doi: 10.1080/14737175.2019.1679627. Epub 2019 Oct 21.

Abstract

Background: This study aims to investigate the current status of feeding intolerance (FI) among patients with severe neurological conditions and to further determine the correlation between FI and their poor prognosis.Methods: This study performed a retrospective analysis of the medical data of 58 patients from January 2017 to December 2017. Patients were divided into two groups according to modified Rankin Scale (mRS) scores. Logistic regression was used to analyze the relevant factors for the poor prognosis of these patients.Results: General data analysis showed that age and diagnosis(stroke) were significantly different between the two groups (P < 0.05). Univariate analysis showed that APACHE II score, vomiting within 3 days of NICU admission, gastrointestinal bleeding within 3 days of NICU admission and occurrence of FI within 3 days of NICU admission were all risk factors for a poor prognosis of these patients(P < 0.05). Multivariate logistic regression analysis showed that FI within 3 days of NICU admission(OR 8.026, 95%CI(1.550-26.039)) and diagnosis(stroke)(OR 10.654, 95%CI (1.746-21.291)) were independent factors for a poor prognosis of patients with severe neurological conditions.Conclusion: The incidence of early FI in stroke patients is correlated with a poor prognosis.

Keywords: Patients with severe neurological conditions; feeding intolerance; modified Rankin Scale assessment; poor prognosis; stroke.

MeSH terms

  • Aged
  • Case-Control Studies
  • Feeding and Eating Disorders / diagnosis*
  • Feeding and Eating Disorders / etiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nervous System Diseases / complications*
  • Nervous System Diseases / diagnosis*
  • Prognosis
  • Retrospective Studies
  • Stroke / complications
  • Stroke / diagnosis