Abstract
To effectively inhibit the growth of breast cancer cells (MDA-MB-231 cells) by the combination method of chemotherapy and magnetic hyperthermia, we fabricated a biomimetic drug delivery (CSiFePNs) system composed of mesoporous silica nanoparticles (MSNs) containing superparamagnetic ferroferric oxide and Paclitaxel (PTX) coated with MDA-MB-231 cell membranes (CMs). In the in vitro cytotoxicity tests, the MDA-MB-231 cells incubated with CSiFePNs obtained IC50 value of 0.8 μgL-1, 3.5-fold higher than that of SiFePNs. The combination method of chemotherapy and magnetic hyperthermia can effectively inhibit the growth of MDA-MB-231 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / administration & dosage*
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Biological Transport, Active
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Biomimetic Materials / administration & dosage
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Biomimetic Materials / chemistry
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Breast Neoplasms / therapy*
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Cell Line, Tumor
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Cell Membrane / metabolism
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Cell Proliferation / drug effects
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Combined Modality Therapy
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Drug Delivery Systems
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Female
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Humans
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Hyperthermia, Induced / methods
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Magnetite Nanoparticles / administration & dosage*
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Magnetite Nanoparticles / chemistry
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Magnetite Nanoparticles / ultrastructure
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Paclitaxel / administration & dosage*
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Silicon Dioxide / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Magnetite Nanoparticles
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Silicon Dioxide
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Paclitaxel