Clinical/Translational Aspects of Advanced Glycation End-Products

Chang Zeng; Yuanyuan Li; Jingzhi Ma; Lina Niu; Franklin R Tay

doi:10.1016/j.tem.2019.08.005

Clinical/Translational Aspects of Advanced Glycation End-Products

Trends Endocrinol Metab. 2019 Dec;30(12):959-973. doi: 10.1016/j.tem.2019.08.005. Epub 2019 Oct 6.

Authors

Chang Zeng¹, Yuanyuan Li², Jingzhi Ma³, Lina Niu⁴, Franklin R Tay⁵

Affiliations

¹ Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
² State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
³ Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: majingzhi2002@163.com.
⁴ State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China; The Graduate School, Augusta University, Augusta, GA, USA. Electronic address: niulina831013@126.com.
⁵ State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China; The Graduate School, Augusta University, Augusta, GA, USA. Electronic address: ftay@augusta.edu.

PMID: 31597608
DOI: 10.1016/j.tem.2019.08.005

Abstract

Advanced glycation end-products (AGEs) have been implicated in chronic hyperglycemia and age-related diseases. Endogenous AGEs produced by humans generate oxidative stress and activation of inflammatory signaling pathways via AGE-specific receptors. The present review summarizes current knowledge on the pathogenic role of AGEs in chronic noncommunicable diseases. Although correlations exist between glycation and the pathogenesis of these diseases, uncertainties remain in light of recurrent intervention failures of apparently promising animal models to be translated into clinically useful anti-AGE strategies. Future intervention of AGEs or their receptors should embrace more carefully executed clinical trials. Nevertheless, suppressing symptoms via lifetime drug application is unlikely to eliminate the burden of chronic diseases unless deep-rooted lifestyle issues that cause these diseases are simultaneously addressed.

Keywords: advanced glycation end-products; chronic diseases; glycation; lifestyle; receptor for advanced glycation end-products; α-dicarbonyls.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chronic Disease
Glycation End Products, Advanced / metabolism*
Humans
Inflammation / metabolism
Oxidative Stress / physiology
Signal Transduction / physiology

Substances

Glycation End Products, Advanced