Acute pulmonary embolism unmasking underlying chronic thromboembolic pulmonary hypertension and iliac vein compression syndrome

Catheter Cardiovasc Interv. 2020 Feb 15;95(3):462-466. doi: 10.1002/ccd.28525. Epub 2019 Oct 8.

Abstract

We describe the case of a 72-year-old gentleman who was referred to our institution for management of cardiogenic shock from a massive pulmonary embolism. Right heart catheterization revealed a low cardiac index and markedly elevated pulmonary pressures, suggested long-standing venous thromboembolic (VTE) disease that evolved into chronic thromboembolic pulmonary hypertension (CTEPH). The patient was cannulated to veno-arterial extra-corporeal membrane oxygenation and eventually treated with pulmonary embolectomy and thromboendarterectomy. Subsequently discovered inferior vena cava clot and left iliac deep vein thrombosis were treated with suction and mechanical thrombectomy. Intravascular ultrasound of the left lower extremity venous system identified iliac vein compression syndrome (IVCS) as the culprit of the patient's VTE and CTEPH. A left iliac stent was placed and the patient was discharged on Warfarin for anticoagulation. The case illustrates the rapidly expanding armamentarium for VTE treatment and proposes IVCS as a new, potentially underrecognized risk factor for CTEPH.

Keywords: peripheral intervention; pulmonary embolism; pulmonary hypertension; right ventricular dysfunction.

Publication types

  • Case Reports
  • Video-Audio Media

MeSH terms

  • Aged
  • Anticoagulants / therapeutic use
  • Embolectomy
  • Endarterectomy
  • Endovascular Procedures / instrumentation
  • Extracorporeal Membrane Oxygenation
  • Hemodynamics
  • Humans
  • Hypertension, Pulmonary / diagnostic imaging
  • Hypertension, Pulmonary / etiology*
  • Hypertension, Pulmonary / physiopathology
  • Hypertension, Pulmonary / therapy
  • Male
  • May-Thurner Syndrome / complications*
  • May-Thurner Syndrome / diagnostic imaging
  • May-Thurner Syndrome / physiopathology
  • May-Thurner Syndrome / therapy
  • Pulmonary Embolism / diagnostic imaging
  • Pulmonary Embolism / etiology*
  • Pulmonary Embolism / physiopathology
  • Pulmonary Embolism / therapy
  • Risk Factors
  • Stents
  • Thrombectomy
  • Treatment Outcome
  • Venous Thromboembolism / diagnostic imaging
  • Venous Thromboembolism / etiology
  • Venous Thromboembolism / physiopathology
  • Venous Thromboembolism / therapy*
  • Venous Thrombosis / diagnostic imaging
  • Venous Thrombosis / etiology*
  • Venous Thrombosis / physiopathology
  • Venous Thrombosis / therapy
  • Warfarin / therapeutic use

Substances

  • Anticoagulants
  • Warfarin