Genetically Encoded Fluorescent Calcium and Voltage Indicators

Handb Exp Pharmacol. 2019:260:209-229. doi: 10.1007/164_2019_299.

Abstract

Fluorescent probes that indicate biologically important quantities are widely used for many different types of biological experiments across life sciences. During recent years, limitations of small molecule-based indicators have been overcome by the development of genetically encoded indicators. Here we focus on fluorescent calcium and voltage indicators and point to their applications mainly in neurosciences.

Keywords: GECI application; GEVI application; Genetically encoded calcium indicators; Genetically encoded voltage indicators.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / chemistry*
  • Calcium Signaling*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Neurosciences

Substances

  • Fluorescent Dyes
  • Calcium