The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer

Jingchen Jing; Bo Wang; Peijun Liu

doi:10.7150/ijbs.37008

The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer

Int J Biol Sci. 2019 Sep 7;15(11):2419-2426. doi: 10.7150/ijbs.37008. eCollection 2019.

Authors

Jingchen Jing^{1

2}, Bo Wang^{1

2}, Peijun Liu^{1

2}

Affiliations

¹ Center for Translational Medicine, The First Affiliated Hospital, Xi'an Jiaotong University.
² The Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Abstract

SEC23, the core component of the coat protein complex II (COPII), functions to transport newly synthesized proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus in cells for secretion. SEC23 protein has two isoforms (SEC23A and SEC23B) and their aberrant expression and mutations were reported to cause human diseases and oncogenesis, whereas SEC23A and SEC23B may have the opposite activity in human cancer, for a reason that remains unclear. This review summarizes recent research in SEC23, COPII-vesicle transportation, autophagy, and cancer.

Keywords: COPII-vesicle transportation; SEC23; autophagy; cancer.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autophagy / genetics
Autophagy / physiology*
Biological Transport / genetics
Biological Transport / physiology
Humans
Neoplasms / genetics
Neoplasms / metabolism*
Vesicular Transport Proteins / genetics
Vesicular Transport Proteins / metabolism*

Substances

Vesicular Transport Proteins