MetaMed: Linking Microbiota Functions with Medicine Therapeutics

Han Zhao; Shaliu Fu; Yifei Yu; Zhanbing Zhang; Ping Li; Qin Ma; Wei Jia; Kang Ning; Shen Qu; Qi Liu

doi:10.1128/mSystems.00413-19

MetaMed: Linking Microbiota Functions with Medicine Therapeutics

mSystems. 2019 Oct 8;4(5):e00413-19. doi: 10.1128/mSystems.00413-19.

Authors

Han Zhao^#¹, Shaliu Fu^#¹, Yifei Yu¹, Zhanbing Zhang¹, Ping Li¹, Qin Ma², Wei Jia³, Kang Ning⁴, Shen Qu⁵, Qi Liu^{5

6}

Affiliations

¹ Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China.
² Department of Mathematics and Statistics, South Dakota State University, Brookings, South Dakota, USA.
³ R&D Information, Innovation Center China, AstraZeneca, Shanghai, China.
⁴ School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
⁵ Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, and Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai, China qushencn@hotmail.com qiliu@tongji.edu.cn.
⁶ Department of Ophthalmology, Ninghai First Hospital, Ninghai, Zhejiang, China.

^# Contributed equally.

Abstract

Understanding how the human microbiome affects human health has consequences for treating disease and minimizing unwanted side effects in clinical research. Here, we present MetaMed (http://metamed.rwebox.com/index), a novel and integrative system-wide correlation mapping system to link bacterial functions and medicine therapeutics, providing novel hypotheses for deep investigation of microbe therapeutic effects on human health. Furthermore, comprehensive relationships between microbes living in the environment and drugs were discovered, providing a rich source for discovering microbiota metabolites with great potential for pharmaceutical applications.

Keywords: biosynthetic gene clusters; medicine therapeutics; metabolism; microbiota.