Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders

Ahmad Al-Saffar; Shota Takemi; Hiwa K Saaed; Ichiro Sakata; Takafumi Sakai

doi:10.1016/j.bpg.2019.101633

Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders

Best Pract Res Clin Gastroenterol. 2019 Jun-Aug:40-41:101633. doi: 10.1016/j.bpg.2019.101633. Epub 2019 Jul 26.

Authors

Ahmad Al-Saffar¹, Shota Takemi², Hiwa K Saaed³, Ichiro Sakata⁴, Takafumi Sakai⁵

Affiliations

¹ Department of Medical Sciences, Gastroeneterology & Hepatology, Uppsala University Hospital, 751 85, Uppsala, Sweden. Electronic address: ahmad.al-saffar@medsci.uu.se.
² Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama, 338-8570, Japan. Electronic address: shtakemi@gmail.com.
³ Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Sulaymaniyah, Iraq. Electronic address: hiwa.saaed@univsul.edu.iq.
⁴ Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama, 338-8570, Japan. Electronic address: isakata@mail.saitama-u.ac.jp.
⁵ Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama, 338-8570, Japan; Area of Life-NanoBio, Division of Strategy Research, Graduate School of Science and Engineering, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama, 338-8570, Japan. Electronic address: tsakai@mail.saitama-u.ac.jp.

PMID: 31594654
DOI: 10.1016/j.bpg.2019.101633

Abstract

Alteration in the gastrointestinal (GI) motility and transit comprises an important component of the functional gastrointestinal disorders (FGID). Available animal GI motility and transit models are to study symptoms (delayed gastric emptying, constipation, diarrhea) rather than biological markers to develop an effective treatment that targets the underlying mechanism of altered GI motility in patients. Animal data generated from commonly used methods in human like scintigraphy, breath test and wireless motility capsule may directly translate to the clinic. However, species differences in the control mechanism or pharmacological responses of GI motility may compromise the predictive and translational value of the preclinical data to human. In this review we aim to provide a summary on animal models used to mimic GI motility alteration in FGID, and the impact of the species differences in the physiological and pharmacological responses on the translation of animal GI motility and transit data to human.

Keywords: Animal model; Functional gastrointestinal disorders; Gastrointestinal motility.

Publication types

Review

MeSH terms

Animals
Female
Gastrointestinal Diseases / diagnosis*
Gastrointestinal Motility / physiology*
Gastrointestinal Transit / physiology*
Humans
Male
Treatment Outcome