Optimizing product quality in molecular farming

Andreas Schiermeyer

doi:10.1016/j.copbio.2019.08.012

Optimizing product quality in molecular farming

Curr Opin Biotechnol. 2020 Feb:61:15-20. doi: 10.1016/j.copbio.2019.08.012. Epub 2019 Oct 5.

Author

Andreas Schiermeyer¹

Affiliation

¹ Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Forckenbeckstrasse 6, 52074, Aachen, Germany. Electronic address: andreas.schiermeyer@ime.fraunhofer.de.

PMID: 31593785
DOI: 10.1016/j.copbio.2019.08.012

Abstract

The production of biopharmaceuticals in plant-based systems had faced several challenges that hampered broader adoption of this technology. In recent years, various plant production hosts have been improved by genetic engineering approaches to overcome obstacles with regard to post-translational modifications and integrity of target proteins. Together with optimized extraction and purification processes, those advances have put plant molecular farming in a more competitive position compared to established production systems. Certain biopharmaceuticals can be derived from plant systems with unique desired properties, qualifying them as biobetters.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biological Products*
Genetic Engineering
Molecular Farming*
Plants, Genetically Modified / genetics
Protein Processing, Post-Translational
Recombinant Proteins

Substances

Biological Products
Recombinant Proteins