Gamma Delta T Cell Function in Ruminants

Mariana Guerra-Maupome; Jamison R Slate; Jodi L McGill

doi:10.1016/j.cvfa.2019.08.001

Gamma Delta T Cell Function in Ruminants

Vet Clin North Am Food Anim Pract. 2019 Nov;35(3):453-469. doi: 10.1016/j.cvfa.2019.08.001.

Authors

Mariana Guerra-Maupome¹, Jamison R Slate¹, Jodi L McGill²

Affiliations

¹ Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, 1907 Christensen Drive, VMRI Building 5, Ames, IA 50010, USA.
² Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, 1907 Christensen Drive, VMRI Building 5, Ames, IA 50010, USA. Electronic address: jlmcgill@iastate.edu.

PMID: 31590897
DOI: 10.1016/j.cvfa.2019.08.001

Abstract

Gamma delta (γδ) T cells constitute a major lymphocyte population in peripheral blood and epithelial surfaces. They play nonredundant roles in host defense against diverse pathogens. Although γδ T cells share functional features with other cells of the immune system, their distinct methods of antigen recognition, rapid response, and tissue tropism make them a unique effector population. This review considers the current state of our knowledge on γδ T cell biology in ruminants and the important roles played by this nonconventional T cell population in protection against several infectious diseases of veterinary and zoonotic importance.

Keywords: Bovine; Gamma delta T cells; Immune response to intracellular pathogens; Nonconventional T cells; Ruminant; Veterinary immunology; Workshop cluster 1.

Publication types

Review

MeSH terms

Animals
Cattle
Intraepithelial Lymphocytes / immunology*
Receptors, Antigen, T-Cell, gamma-delta / immunology*
Ruminants / immunology*
Sheep

Substances

Receptors, Antigen, T-Cell, gamma-delta