Abstract
Novel 7-trifluoromethyl-7-deazapurine ribonucleoside analogs (13a-c) and their Protides (15a-c) were successfully synthesized from ribolactol or 1-α-bromo-ribose derivatives using Silyl-Hilbert-Johnson or nucleobase-anion substitution reactions followed by key aromatic trifluoromethyl substitution. Newly prepared compounds were evaluated against a panel of RNA viruses, including HCV, Ebola or Zika viruses.
Keywords:
7-trifluoromethyl-7-deazapurine ribonucleoside; RNA viruses; Silyl-Hilbert-Johnson; protides.
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Ebolavirus / drug effects
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Hepacivirus / drug effects
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Purines / chemical synthesis
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Purines / chemistry
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Purines / pharmacology*
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Ribonucleosides / chemical synthesis
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Ribonucleosides / chemistry
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Ribonucleosides / pharmacology*
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Zika Virus / drug effects
Substances
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7-deazapurine
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Antiviral Agents
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Prodrugs
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Purines
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Ribonucleosides