Levels of syndecan-1 and hyaluronan in early- and late-onset preeclampsia

Abstract

Objective: The study aimed to assess serum levels of syndecan-1 (SDC-1) and hyaluronan (HA) in patients with early- and late-onset preeclampsia (PE).

Study design: Blood samples were collected in the third trimester of pregnancy from 20 women with early-onset PE, 20 with late-onset PE, and 20 with normal pregnancy for the assessment of serum levels of SDC-1 and HA as markers of endothelial injury. PE was categorized as early-onset when diagnosed at <34 weeks of gestation and as late-onset when diagnosed at ≥34 weeks of gestation.

Main outcome measures: The degree of endothelial injury in different forms of preeclampsia expressed by serum concentrations of SDC-1 and HA.

Results: Concentration of HA was significantly higher and the level of SDC-1 was significantly lower in patients with PE than in the control group. However, the concentrations of both HA and SDC-1 did not differ significantly between the two groups of PE.

Conclusions: Degree of endothelium injury is comparable in patients with early- and late-onset PE.

Keywords: Endothelial injury; Glycocalyx; Placental insufficiency; Preeclampsia.