A personally guided tour on some of our data with the Ames assay-A tribute to Professor Bruce Ames

Mutat Res Genet Toxicol Environ Mutagen. 2019 Oct:846:503094. doi: 10.1016/j.mrgentox.2019.503094. Epub 2019 Sep 9.

Abstract

In contributing to this Special Issue of Mutation Research dedicated to Professor Bruce N. Ames in recognition of his 90th birthday in December 2018, we intend to portray the importance not only of the Ames Salmonella/mammalian-microsome mutagenicity assay in some of our studies over the years, but also the importance of the insight that Bruce Ames brought to the field of genetic toxicology.

Keywords: Ames assay; Biomonitoring; Human CYP expression strains; Lipoproteins; Metabolic activation systems; Occupational exposure; Urinary mutagenicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Activation, Metabolic
  • Air Pollutants, Occupational / toxicity
  • Animals
  • Cytochrome P-450 Enzyme System / metabolism
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Flavonoids / chemistry
  • Flavonoids / toxicity
  • Genetic Engineering
  • Humans
  • Microsomes, Liver / enzymology
  • Molecular Structure
  • Mutagenicity Tests* / methods
  • Mutagens / toxicity
  • Nevirapine / chemistry
  • Nevirapine / toxicity
  • Occupational Exposure
  • Quercetin / toxicity
  • Rats
  • Salmonella / drug effects*
  • Salmonella / genetics
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Species Specificity
  • Toxicology / methods
  • Urine / chemistry

Substances

  • Air Pollutants, Occupational
  • Flavonoids
  • Mutagens
  • Cytochrome P-450 Enzyme System
  • Nevirapine
  • Quercetin