Abstract
In contributing to this Special Issue of Mutation Research dedicated to Professor Bruce N. Ames in recognition of his 90th birthday in December 2018, we intend to portray the importance not only of the Ames Salmonella/mammalian-microsome mutagenicity assay in some of our studies over the years, but also the importance of the insight that Bruce Ames brought to the field of genetic toxicology.
Keywords:
Ames assay; Biomonitoring; Human CYP expression strains; Lipoproteins; Metabolic activation systems; Occupational exposure; Urinary mutagenicity.
Copyright © 2019 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Activation, Metabolic
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Air Pollutants, Occupational / toxicity
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Animals
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Cytochrome P-450 Enzyme System / metabolism
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Escherichia coli / drug effects
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Escherichia coli / genetics
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Flavonoids / chemistry
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Flavonoids / toxicity
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Genetic Engineering
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Humans
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Microsomes, Liver / enzymology
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Molecular Structure
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Mutagenicity Tests* / methods
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Mutagens / toxicity
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Nevirapine / chemistry
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Nevirapine / toxicity
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Occupational Exposure
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Quercetin / toxicity
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Rats
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Salmonella / drug effects*
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Salmonella / genetics
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Salmonella typhimurium / drug effects
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Salmonella typhimurium / genetics
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Species Specificity
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Toxicology / methods
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Urine / chemistry
Substances
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Air Pollutants, Occupational
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Flavonoids
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Mutagens
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Cytochrome P-450 Enzyme System
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Nevirapine
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Quercetin