Smelling Danger: Olfactory Stem Cells Control Immune Defense during Chronic Inflammation

Justin Rustenhoven; Jonathan Kipnis

doi:10.1016/j.stem.2019.09.006

Smelling Danger: Olfactory Stem Cells Control Immune Defense during Chronic Inflammation

Cell Stem Cell. 2019 Oct 3;25(4):449-451. doi: 10.1016/j.stem.2019.09.006.

Authors

Justin Rustenhoven¹, Jonathan Kipnis²

Affiliations

¹ Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA 22908, USA; Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: jr9na@virginia.edu.
² Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA 22908, USA; Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: kipnis@virginia.edu.

PMID: 31585089
DOI: 10.1016/j.stem.2019.09.006

Abstract

Neurogenesis is critical to continuously replacie olfactory neurons but is impaired during chronic inflammatory rhinosinusitis. In this issue of Cell Stem Cell, Chen et al. (2019) describe the inflammation-induced switching of olfactory stem cells from a regenerative phenotype to one participating in immune defense; this process contributes to deficient replacement of olfactory sensory neurons.

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MeSH terms

Humans
Inflammation
Nerve Regeneration*
Neurogenesis
Olfactory Receptor Neurons*
Stem Cells