Access to Enantiopure Advanced Intermediates en Route to Madangamines

Celeste Are; Maria Pérez; Roberto Ballette; Stefano Proto; Federica Caso; Nihan Yayik; Joan Bosch; Mercedes Amat

doi:10.1002/chem.201904045

Access to Enantiopure Advanced Intermediates en Route to Madangamines

Chemistry. 2019 Dec 10;25(69):15929-15933. doi: 10.1002/chem.201904045. Epub 2019 Nov 12.

Authors

Celeste Are¹, Maria Pérez², Roberto Ballette¹, Stefano Proto¹, Federica Caso¹, Nihan Yayik¹, Joan Bosch¹, Mercedes Amat¹

Affiliations

¹ Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, 08028, Barcelona, Spain.
² Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, and Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921, Santa Coloma, de Gramanet, Spain.

PMID: 31584737
DOI: 10.1002/chem.201904045

Abstract

The synthesis of enantiopure ABCE and ABCD tetracyclic advanced intermediates en route to madangamine alkaloids and studies for the construction of the triunsaturated 15-membered D ring of madangamine B and the saturated 13-membered D ring of madangamine E are reported.

Keywords: alkaloids; macrocycles; madangamines; skipped dienes; total synthesis.

Abstract

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