Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity

Chem Commun (Camb). 2019 Oct 24;55(86):12904-12907. doi: 10.1039/c9cc05266f.

Abstract

A novel type of hydrogen peroxide (H2O2)-activated diazeniumdiolate based on an α-ketoamide moietey was developed as a nitric oxide (NO) donor. KA-NO-4 inhibited lung cancer cells with submicromolar activity. The H2O2-responsive behaviour of KA-NO-4 was thoroughly investigated. The NO-centered mechanism of action of KA-NO-4 was intracellularly studied.

MeSH terms

  • Amides / chemistry*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects
  • Azo Compounds / chemistry*
  • Azo Compounds / pharmacology
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Humans
  • Hydrogen Peroxide / chemistry*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Nitric Oxide / metabolism
  • Nitric Oxide Donors / chemistry*
  • Nitric Oxide Donors / pharmacology

Substances

  • Amides
  • Antineoplastic Agents
  • Azo Compounds
  • Nitric Oxide Donors
  • diazeniumdiolate
  • Nitric Oxide
  • Hydrogen Peroxide