Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial

Nutrients. 2019 Oct 1;11(10):2337. doi: 10.3390/nu11102337.

Abstract

Age-related strength and muscle mass loss is further increased after acute periods of inactivity. To avoid this, resistance training has been proposed as an effective countermeasure, but the additional effect of a protein supplement is not so clear. The aim of this study was to examine the effect of a whey protein supplement enriched with leucine after resistance training on muscle mass and strength gains in a post-hospitalized elderly population. A total of 28 participants were included and allocated to either protein supplementation or placebo supplementation following resistance training for 12 weeks (2 days/week). Physical function (lower and upper body strength, aerobic capacity and the Short Physical Performance Battery (SPPB) test), mini nutritional assessment (MNA) and body composition (Dual X-ray Absorptiometry) were assessed at baseline and after 12 weeks of resistance training. Both groups showed improvements in physical function after the intervention (p < 0.01), but there were no further effects for the protein group (p > 0.05). Muscle mass did not improve after resistance training in either group (p > 0.05). In conclusion, 12 weeks of resistance training are enough to improve physical function in a post-hospitalized elderly population with no further benefits for the protein-supplemented group.

Keywords: aging; elderly; leucine; muscle mass; protein supplementation; resistance training; strength; whey protein.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Dietary Supplements* / adverse effects
  • Female
  • Humans
  • Leucine / administration & dosage*
  • Leucine / adverse effects
  • Male
  • Muscle Contraction*
  • Muscle Strength*
  • Muscle, Skeletal / physiopathology*
  • Nutritional Status
  • Nutritive Value
  • Patient Discharge
  • Prospective Studies
  • Recovery of Function
  • Resistance Training* / adverse effects
  • Sarcopenia / diagnosis
  • Sarcopenia / physiopathology
  • Sarcopenia / therapy*
  • Single-Blind Method
  • Spain
  • Time Factors
  • Treatment Outcome
  • Whey Proteins / administration & dosage*
  • Whey Proteins / adverse effects

Substances

  • Whey Proteins
  • Leucine