Effective removal matrix interferences by a modified QuEChERS based on the molecularly imprinted polymers for determination of 84 polychlorinated biphenyls and organochlorine pesticides in shellfish samples

Abstract

A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) procedure combined with GC-MS/MS detection approach using a dynamic multiple reaction monitoring (DMRM) mode was successfully applied for the simultaneous analysis of 84 polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in shellfish samples. The novel molecular imprinted polymers (MIPs) were synthesized by precipitation polymerization and characterized by Scanning electron microscopy, Brunauer-Emmett-Teller, Fourier transform infrared spectra and adsorption experiment. The MIPs exhibited good adsorption capability to pigment coextractives in shellfish samples without the loss of analytes compared with other sorbents. Under optimal conditions, spiked experiments in sinonovacula, mussel, and clam at 10.0-100.0 μg/kg concentrations showed excellent recoveries ranging from 70% to 120% for all analytes with the relative standard deviations of <10%. The developed method showed good linearity with the correlation coefficient above 0.9980, and the limits of quantification were in the range of 0.01-9.02 μg/kg. The developed QuEChERS procedure combined with GC-MS/MS was successfully applied to 84 PCBs and OCPs residues detection in shellfish samples.

Keywords: Molecularly imprinted polymers; Organochlorine pesticides (OCPs); Pigments; Polychlorinated biphenyls (PCBs); QuEChERS.