Abstract
Mitochondria targeting sensitizers are continuing to gain importance in photodynamic therapy (PDT). Members of the 90 kDa heat shock protein (Hsp90) family, including TRAP1 (Hsp75), are overexpressed in cancer cells and help to control the antiapoptotic protein activity. The present work introduces an Hsp90 inhibitor-mitochondria targeting indocyanine dye conjugate (IR-PU) for high PDT efficacy.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Cell Line
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Cell Survival / drug effects
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology
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Fluorescent Dyes / chemistry
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HSP90 Heat-Shock Proteins / antagonists & inhibitors*
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Humans
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Indocyanine Green / chemistry*
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Indocyanine Green / pharmacology
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Mice
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Mice, Nude
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Mitochondria / metabolism*
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Neoplasm Transplantation
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Optical Imaging / methods
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Photochemotherapy / methods
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology
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Singlet Oxygen / metabolism
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Fluorescent Dyes
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HSP90 Heat-Shock Proteins
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Photosensitizing Agents
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Singlet Oxygen
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Indocyanine Green