FDG PET/CT with SPM Analysis in Early Diagnosis of Clinically Suspected Osmotic Demyelination Syndrome with Non-contributory MRI

Nikhil Seniaray; Ritu Verma; Rajeev Ranjan; Ethel Belho; Dharmender Malik; Vanshika Gupta; Abhinav Jaimini; Harsh Mahajan

doi:10.4103/ijnm.IJNM_95_19

FDG PET/CT with SPM Analysis in Early Diagnosis of Clinically Suspected Osmotic Demyelination Syndrome with Non-contributory MRI

Indian J Nucl Med. 2019 Oct-Dec;34(4):321-323. doi: 10.4103/ijnm.IJNM_95_19.

Authors

Nikhil Seniaray¹, Ritu Verma¹, Rajeev Ranjan², Ethel Belho¹, Dharmender Malik¹, Vanshika Gupta¹, Abhinav Jaimini³, Harsh Mahajan¹

Affiliations

¹ Department of Nuclear Medicine and PET/CT, Mahajan Imaging Center, Sir Ganga Ram Hospital, New Delhi, India.
² Department of Neurology, Sir Ganga Ram Hospital, New Delhi, India.
³ Department of Nuclear Medicine and PET/CT, Institute of Nuclear Medicine and Allied sciences, New Delhi, India.

Abstract

Early diagnosis is imperative for adequate management of patients with osmotic demyelination syndrome (ODS), which is usually a result of rapid shifts of osmolality secondary to rapid correction of hyponatremia. Magnetic resonance imaging (MRI) with its special sequences is the investigation of choice for early detection of the osmotic changes in the brain. We report a case of clinically suspected ODS with noncontributory MRI and positive fluoro-2-deoxy-d-glucose positron emission tomography (FDG PET) scan with statistical parametric mapping (SPM) analysis, which localized the focal hypermetabolism in the basal ganglia, thalamus, pons, and cerebellum.

Keywords: FDG PET; MRI; SPM.