Porcine growth plate experimental study and estimation of human pediatric growth plate properties

Ming Shen; Shengxiong Liu; Xin Jin; Haojie Mao; Feng Zhu; Tal Saif; Runzhou Zhou; Haonan Fan; Paul C Begeman; Clifford C Chou; King H Yang

doi:10.1016/j.jmbbm.2019.103446

Porcine growth plate experimental study and estimation of human pediatric growth plate properties

J Mech Behav Biomed Mater. 2020 Jan:101:103446. doi: 10.1016/j.jmbbm.2019.103446. Epub 2019 Sep 23.

Authors

Ming Shen¹, Shengxiong Liu², Xin Jin³, Haojie Mao⁴, Feng Zhu⁵, Tal Saif³, Runzhou Zhou³, Haonan Fan³, Paul C Begeman³, Clifford C Chou³, King H Yang⁶

Affiliations

¹ Bioengineering Center, Wayne State University, Detroit, MI, USA. Electronic address: ex9034@wayne.edu.
² Chongqing University of Technology, Chongqing, China.
³ Bioengineering Center, Wayne State University, Detroit, MI, USA.
⁴ Western University, Mechanical & Materials Engineering, London, Ontario, Canada.
⁵ Embry-Riddle Aeronautical University, Daytona Beach, FL, USA.
⁶ Bioengineering Center, Wayne State University, Detroit, MI, USA. Electronic address: aa0007@wayne.edu.

PMID: 31577984
DOI: 10.1016/j.jmbbm.2019.103446

Abstract

Growth plate (GP) is a type of tissue widely found in child's immature skeleton. It may have significant influence on the overall injury pattern since it has distinguishing mechanical properties compared to the surrounding bony tissue. For more accurate material modeling and advanced pediatric human body modeling, it is imperative to investigate the material property of GPs in different loading conditions. In this study, a series of tensile and shearing experiments on porcine bone-GP-bone units were carried out. Total 113 specimens of bone-GP-bone unit from the femoral head, distal femur, and proximal tibia of four 20-weeks-old piglets were tested, under different strain rates (average 0.0053 to 1.907 s^-1 for tensile tests, and 0.0085 to 3.037 s^-1 for shearing tests). Randomized block ANOVA was conducted to determine the effects of anatomic region and strain rate on the material properties of GPs. It was found that, strain rate is a significant factor for modulus and ultimate stress for both tensile and shearing tests; the ultimate strains are not sensitive to the input factors in both tensile and shearing tests; the GPs at knee region could be grouped due to similar properties, but statistically different from the femoral head GP. Additionally, the tensile test data from the experimental study were comparing to the limited data obtained from tests on human subjects reported in the literature. An optimal conversion factor was derived to correlate the material properties of 20-week-old piglet GPs and 10 YO child GPs. As a result, the estimated material properties of 10 YO child GPs from different regions in different loading conditions became available given the conversion law stays legitimate. These estimated material properties for 10 YO child GPs were reported in the form of tensile and shearing stress-strain curves and could be subsequently utilized for human GP tissue material modeling and child injury mechanism studies.

Keywords: Child human body modeling; Growth plate; Mechanical property; Shearing test; Strain rate effect; Tensile test.

MeSH terms

Animals
Child
Growth Plate / physiology*
Humans
Mechanical Tests
Stress, Mechanical
Swine
Tensile Strength
Weight-Bearing