Mucoadhesive micro-composites: Chitosan coated halloysite nanotubes for sustained drug delivery

Sana Sharif; Ghulam Abbas; Muhammad Hanif; Andreas Bernkop-Schnürch; Aamir Jalil; Muhammad Yaqoob

doi:10.1016/j.colsurfb.2019.110527

Mucoadhesive micro-composites: Chitosan coated halloysite nanotubes for sustained drug delivery

Colloids Surf B Biointerfaces. 2019 Dec 1:184:110527. doi: 10.1016/j.colsurfb.2019.110527. Epub 2019 Sep 24.

Authors

Sana Sharif¹, Ghulam Abbas², Muhammad Hanif³, Andreas Bernkop-Schnürch⁴, Aamir Jalil⁵, Muhammad Yaqoob⁶

Affiliations

¹ Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60000, Pakistan. Electronic address: sanarao94@hotmail.com.
² Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60000, Pakistan. Electronic address: ghulamabbas@gcuf.edu.pk.
³ Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60000, Pakistan; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: muhammad.hanif@bzu.edu.pk.
⁴ Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: Andreas.Bernkop@uibk.ac.at.
⁵ Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: Aamir.Jalil@student.uibk.ac.at.
⁶ Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: muhammad.yaqoob@student.uibk.ac.at.

PMID: 31577976
DOI: 10.1016/j.colsurfb.2019.110527

Abstract

It was aim of this study to synthesize micro-composites comprising halloysite nanotubes (HNTs) and the cationic polymer chitosan as mucoadhesive sustained release drug delivery system. Micro-composites were characterized for preparation yield, size, micromeritic properties and swelling behavior. Chemical composition of micro-composites was characterized by FTIR, XRD and TGA. Scanning electron microscopy (SEM) was used to study their surface morphology. Micro-composites were studied for adhesion on intestinal mucosa as well as for release behavior of metoclopramide hydrochloride used as model drug. Preparation yield was found to be in the range of 35.14 ± 1.5-53.97 ± 5.23%. Micro-composites exhibited a mean size range of 0.151 ± 0.49 μm. SEM showed a spherical shape with rough curved porous surface. Micro-composites exhibited excellent flowability and maximum swelling at acidic pH. XRD results showed crystalline nature of micro-composites. HNTs/micro-composites with highest concentration of chitosan displayed maximum adherence of 89 ± 1.79% on intestinal mucosa after 3 h. Drug release recorded was 66.8% at pH 1.2 and 46.7% at pH 5.5 within 25 h. Chitosan coated HNTs showed remarkable mucoadhesion and sustained release of metoclopramide proving their suitability as mucoadhesive drug delivery system.

Keywords: Chitosan; Halloysite nanotubes; Micro-composites; Mirco-composites; Mucoadhesion; Sustained drug release.

MeSH terms

Adhesiveness
Chitosan / chemistry*
Drug Delivery Systems*
Drug Liberation
Humans
Intestinal Mucosa / chemistry
Metoclopramide / chemistry*
Nanotubes / chemistry*
Particle Size
Porosity
Surface Properties

Substances

Chitosan
Metoclopramide