Breathe: Your Mitochondria Will Do the Rest… If They Are Healthy!

Cell Metab. 2019 Oct 1;30(4):628-629. doi: 10.1016/j.cmet.2019.09.004.

Abstract

Dysfunctions of the mitochondrial electron transport chain cause severe, currently untreatable, diseases in humans. A new study by Jain et al. (2019) reports increased oxygen levels in the brain of complex-I-deficient mice. Reducing the O2 levels by hypoxia, carbon monoxide, or anemia, improved the clinical phenotype and prolonged the lifespan of the mouse model.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Brain
  • Humans
  • Hyperoxia*
  • Leigh Disease*
  • Mice
  • Mitochondria
  • Oxygen
  • Rest

Substances

  • Oxygen