Substrates of PHD

Cell Metab. 2019 Oct 1;30(4):626-627. doi: 10.1016/j.cmet.2019.08.008.

Abstract

The discovery of prolyl hydroxylase domain proteins (PHDs) as key enzymes in the hypoxia inducible factor (HIF) pathway has been followed by reports of a multitude of non-HIF substrates of PHD. Reporting in eLife, Cockman et al. (2019) find a surprising lack of detectable PHD activity toward any of them.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Ankyrin Repeat*
  • Humans
  • Hydroxylation
  • Hypoxia
  • Procollagen-Proline Dioxygenase
  • Proteomics*

Substances

  • Procollagen-Proline Dioxygenase