Effect of Pediatric Influenza Vaccination on Antibiotic Resistance, England and Wales

Emerg Infect Dis. 2020 Jan;26(1):138-142. doi: 10.3201/eid2601.191110.

Abstract

Vaccines against viral infections have been proposed to reduce prescribing of antibiotics and thereby help control resistant bacterial infections. However, by combining published data sources, we predict that pediatric live attenuated influenza vaccination in England and Wales will not substantially reduce antibiotic consumption or adverse health outcomes associated with antibiotic resistance.

Keywords: England; LAIV; United Kingdom; Wales; antibacterial agents; antimicrobial resistance; attenuated; bacterial infections; child; cost savings; drug resistance; human; influenza; influenza vaccines; mathematical model; microbial; prescriptions; primary healthcare; referral and consultation; respiratory infections; vaccination; vaccine-preventable diseases; vaccines; viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Infections / drug therapy
  • Bacterial Infections / epidemiology
  • Child
  • Child, Preschool
  • Drug Resistance, Bacterial*
  • England / epidemiology
  • Humans
  • Infant
  • Infant, Newborn
  • Influenza Vaccines / therapeutic use*
  • Influenza, Human / prevention & control
  • Middle Aged
  • Vaccines, Attenuated / therapeutic use
  • Wales / epidemiology
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Influenza Vaccines
  • Vaccines, Attenuated