IRE1 Signaling As a Putative Therapeutic Target in Influenza Virus-induced Pneumonia

Am J Respir Cell Mol Biol. 2019 Oct;61(4):537-540. doi: 10.1165/rcmb.2019-0123LE.

Authors

Carole Schmoldt^{1

2}, Ana Ivonne Vazquez-Armendariz^{1

2}, Irina Shalashova^{1

2}, Balachandar Selvakumar^{1

2

3

4}, Corinna M Bremer^{1

2}, Christin Peteranderl^{1

2}, Roxana Wasnick^{1

2}, Biruta Witte⁵, Stefan Gattenlöhner^{5

6}, Ludger Fink⁷, István Vadász^{1

2}, Rory E Morty^{1

2

3}, Stephan Pleschka^{6

8}, Werner Seeger^{1

2

3

4}, Andreas Günther^{1

2}, Susanne Herold^{1

2}

Affiliations

¹ Universities of Giessen and Marburg Lung CenterGiessen, Germany.
² Excellence Cluster Cardio-Pulmonary InstituteGiessen, Germany.
³ Max Planck Institute for Heart and Lung ResearchBad Nauheim, Germany.
⁴ Instituto de Investigación en Biomedicina de Buenos AiresBuenos Aires, Argentina.
⁵ University Hospital GiessenGiessen, Germany.
⁶ Justus-Liebig University GiessenGiessen, Germany.
⁷ Institute of Pathology and CytologyWetzlar, Germanyand.
⁸ Institute of Medical VirologyGiessen, Germany.

PMID: 31573336
DOI: 10.1165/rcmb.2019-0123LE

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alveolar Epithelial Cells / drug effects*
Alveolar Epithelial Cells / enzymology
Animals
Apoptosis / drug effects
Cells, Cultured
Endoplasmic Reticulum Stress / drug effects
Endoribonucleases / antagonists & inhibitors*
Endoribonucleases / physiology
Gene Expression Regulation, Viral / drug effects
Humans
Hymecromone / analogs & derivatives
Influenza A Virus, H1N1 Subtype / genetics
Influenza A Virus, H1N1 Subtype / physiology
Influenza, Human / complications*
Influenza, Human / drug therapy
Mice
Mice, Inbred C57BL
Molecular Targeted Therapy*
Orthomyxoviridae Infections / complications*
Orthomyxoviridae Infections / drug therapy
Pneumonia, Viral / drug therapy*
Pneumonia, Viral / enzymology
Pneumonia, Viral / etiology
Protein Serine-Threonine Kinases / antagonists & inhibitors*
Protein Serine-Threonine Kinases / physiology
Salicylanilides / therapeutic use*
Transcription, Genetic
Unfolded Protein Response / drug effects
Viral Proteins / biosynthesis
Viral Proteins / genetics
Virus Replication / drug effects

Substances

4-methylumbelliferone 8-carbaldehyde
Salicylanilides
Viral Proteins
Hymecromone
metabromsalan
ERN1 protein, human
Protein Serine-Threonine Kinases
Endoribonucleases