Iatrogenic perforation is a procedural incident that may occur in endodontic treatments of primary and/or permanent teeth. Prognosis may be favorable if a complete seal with biomaterial is immediately established. Several materials, including glass-ionomer cement (GIC), have been used to seal different types of perforation defects. GIC is considered to be biocompatible, nontoxic, and non-irritating, and promotes bone healing and cementum regeneration. In the present case, GIC was used to treat an endodontic perforation. The perforation was cleaned with periodontal curettes and sealed with GIC. A reintervention was needed in which sealing was performed with a light-curing GIC, a material that was less rough than the initial material used. After 2 years, the absence of periradicular radiolucent lesions, pain, and swelling along with functional tooth stability indicated a successful outcome of sealing perforation in the case.