Mechanisms Underlying Therapeutic Effects Of Traditional Chinese Medicine On Gastric Cancer

Linjun Yang; Liqian Zhao; Tianni Zeng; Hong Chen; Jingjing Shao; Song Yang; Zheying Tao; Jingqin Yang; Tongke Chen; Xiaokun Lin; Xiwen Chen; Mosheng Tang

doi:10.2147/CMAR.S218214

Mechanisms Underlying Therapeutic Effects Of Traditional Chinese Medicine On Gastric Cancer

Cancer Manag Res. 2019 Sep 16:11:8407-8418. doi: 10.2147/CMAR.S218214. eCollection 2019.

Authors

Affiliations

¹ Department of Laboratory Animal Centre, Laboratory Animal Centre, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
² Department of Pediatric Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
³ Department of Radiotherapy and Chemotherapy, Lishui City People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, People's Republic of China.

^# Contributed equally.

Abstract

Gastric cancer (GC) is one of the most common malignant tumors in the world. It is the fourth most common cancer and has the second highest mortality rate globally. Metastasis is an important feature of gastric cancer and is the most common cause of death. Exploring the mechanism underlying the metastasis of gastric cancer and searching for new drug targets has become the focus of several studies. Traditional Chinese medicine may show promise for treatment of gastric cancer. In this review, we report the recent progress in research on the anti-metastasis activity of Chinese medicine, to facilitate clinical development of treatments for gastric cancer.

Keywords: Chinese medicine; angiogenesis; cell cycle; gastric cancer; metastasis.