Abstract
A platinum(ii) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.
MeSH terms
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Animals
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Antineoplastic Agents, Immunological / chemistry
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Antineoplastic Agents, Immunological / pharmacology*
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Cell Death / drug effects
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Esters / chemistry
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Esters / pharmacology*
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Humans
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Ligands
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / immunology
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Lung Neoplasms / pathology
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Mice
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Mice, Inbred C57BL
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Neoplasms, Experimental / drug therapy
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Neoplasms, Experimental / immunology
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Neoplasms, Experimental / pathology
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Organophosphonates / chemistry
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Organophosphonates / pharmacology*
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology*
Substances
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Antineoplastic Agents, Immunological
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Esters
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Ligands
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Organophosphonates
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Organoplatinum Compounds