To investigate the clinical characteristics and prognosis for connective tissue disease (CTD) with cryptococcal meningitis (CM). Methods: Clinical data of 18 patients with CTD complicated with cryptococcal meningitis diagnosed by Rheumatology and Immunology Department, Xiangya Hospital, Central South University from January 2000 to January 2017, were retrospectively analyzed. Results: The common symptoms of CTD patients with CM were headache, fever, nausea, and vomiting. Patients with severe clinical manifestations, such as convulsions and disturbance of consciousness, all died. Logistic regression analysis showed that disturbance of consciousness and decreased peripheral blood lymphocyte count might be the related factors of poor prognosis of CTD patients with CM (P<0.05). The mortality rate of CTD with CM was 61.11%, and the effective rate of treatment for this disease was 38.89%. Conclusion: CTD patients with cryptococcal meningitis have a high risk of death. Severe clinical symptoms, such as disturbance of consciousness and lower peripheral blood lymphocyte count, are associated with its poor prognosis.
目的：分析结缔组织病(connective tissue disease，CTD)合并隐球菌脑膜炎的临床特点及预后。方法：回顾分析2000年1月至2017年1月期间中南大学湘雅医院风湿免疫科诊断的18例CTD合并隐球菌脑膜炎患者的临床资料。结果：CTD合并隐球菌脑膜炎患者的常见症状为头痛、发热、恶心、呕吐，出现抽搐、意识障碍等严重临床表现的患者均死亡。Logistic回归分析表明出现意识障碍、外周血淋巴细胞计数下降是造成CTD合并隐脑预后不良的相关因素(P<0.05)。CTD合并隐球菌脑膜炎的病死率为61.11%，治疗有效率为38.89%。结论：CTD合并隐球菌脑膜炎患者死亡风险高。出现意识障碍、外周血淋巴细胞计数降低与疾病预后不良相关。.