Linagliptin-associated bullous pemphigoid treated with rituximab

BMJ Case Rep. 2019 Sep 30;12(9):e229902. doi: 10.1136/bcr-2019-229902.

Abstract

Dipeptidyl peptidase 4 (DPP-4) inhibitors are increasingly used these days in management of diabetes. There has been reported in a few case reports of increasing association between DPP-4 inhibitor use and bullous pemphigoid (BP). We report a case of association between linagliptin use and BP and subsequent treatment with rituximab.

Keywords: contraindications and precautions; dermatology; drug interactions; endocrine system.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Clobetasol / therapeutic use
  • Dipeptidyl-Peptidase IV Inhibitors / administration & dosage
  • Dipeptidyl-Peptidase IV Inhibitors / adverse effects*
  • Drug Eruptions / drug therapy
  • Drug Eruptions / pathology*
  • Humans
  • Linagliptin / administration & dosage
  • Linagliptin / adverse effects*
  • Male
  • Minocycline / therapeutic use
  • Pemphigoid, Bullous / chemically induced*
  • Pemphigoid, Bullous / pathology
  • Prednisone / therapeutic use
  • Rituximab / therapeutic use*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Dipeptidyl-Peptidase IV Inhibitors
  • Linagliptin
  • Rituximab
  • Clobetasol
  • Minocycline
  • Prednisone