In this study, 3-dimensional (3-D) enhanced brain-function-map generation and estimation methodology is presented. Optical signals were modelled in the form of numerical optimization problem to infer the best existing waveform of canonical hemodynamic response function. Inter-channel activity patterns were also estimated. The estimation of activation of inter-channel gap depends on the minimization of generalized cross-validation. 3-D brain activation maps were produced through inverse discrete cosine transform. The proposed algorithm acquired significant results for 3-D functional maps with high resolution, in comparison with that of 2-D functional t-maps. A comprehensive analysis by exhibiting images corresponding to several layers has also been appended.
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