Disposable Microfluidic Sensor Based on Nanocellulose for Glucose Detection

Khan Mohammad Ahsan Uddin; Ville Jokinen; Farzin Jahangiri; Sami Franssila; Orlando J Rojas; Sampo Tuukkanen

doi:10.1002/gch2.201800079

Disposable Microfluidic Sensor Based on Nanocellulose for Glucose Detection

Glob Chall. 2018 Nov 12;3(2):1800079. doi: 10.1002/gch2.201800079. eCollection 2019 Feb.

Authors

Khan Mohammad Ahsan Uddin¹, Ville Jokinen², Farzin Jahangiri², Sami Franssila², Orlando J Rojas³, Sampo Tuukkanen¹

Affiliations

¹ BioMediTech Institute and Faculty of Biomedical Sciences and Engineering Tampere University of Technology (TUT) Post address: P.O. Box 692 FI-33101 Tampere Finland.
² Department of Chemistry and Materials Science School of Chemical Engineering and Micronova Nanofabrication Centre Aalto University Espoo P.O. Box 13500 FI-00076 Aalto Finland.
³ Department of Bioproducts and Biosystems School of Chemical Engineering Aalto University Espoo P.O. Box 16300 FI-00076 Aalto Finland.

Abstract

Point-of-care devices that are inexpensive, disposable, and environmentally friendly are becoming increasingly predominant in the field of biosensing and biodiagnostics. Here, microfluidics is a suitable option to endow portability and minimal reagent and material consumption. Nanocellulose is introduced to manufacture microfluidic channels and as a storage and immobilization compartment of glucose oxidase. Improved enzymatic activity retention is demonstrated in a simple and disposable point-of-care diagnostic unit that is able to detect glucose from fluid matrices at 0.1 × 10^-3 m concentration and in less than 10 min. It is concluded that the patterning and fluidic technologies that are possible with nanocellulose enable easily scalable multianalyte designs.

Keywords: biosensors; colorimetry; diagnostics; glucose oxidase; nanofibrils.