Gut and oral microbiota in autoimmune liver disease

Fukushima J Med Sci. 2020 Jan 9;65(3):71-75. doi: 10.5387/fms.2019-21. Epub 2019 Sep 27.

Abstract

The gut microbiota plays a key role in the development of chronic inflammatory liver disease. The gut-liver axis involves inflammatory cells, cytokines, and other molecules that cause liver deterioration. Dysbiosis is important in understanding several liver diseases, especially in relation to the development of autoimmune liver disease. The aim of this review is to provide a current overview of alterations in the gut and oral microbiota associated with autoimmune liver diseases.

Keywords: autoimmune hepatitis; gut microbiota; oral microbiota; primary biliary cholangitis.

Publication types

  • Review

MeSH terms

  • Dysbiosis
  • Gastrointestinal Microbiome / physiology*
  • Hepatitis, Autoimmune / etiology*
  • Hepatitis, Autoimmune / microbiology
  • Humans
  • Liver Cirrhosis, Biliary / etiology*
  • Liver Cirrhosis, Biliary / microbiology
  • Mouth / microbiology*