Acne: Transient Arrest in the Homeostatic Host-Microbiota Dialog?

Andrea Szegedi; Zsolt Dajnoki; Tamás Bíró; Lajos Kemény; Dániel Törőcsik

doi:10.1016/j.it.2019.08.006

Acne: Transient Arrest in the Homeostatic Host-Microbiota Dialog?

Trends Immunol. 2019 Oct;40(10):873-876. doi: 10.1016/j.it.2019.08.006. Epub 2019 Sep 26.

Authors

Andrea Szegedi¹, Zsolt Dajnoki², Tamás Bíró³, Lajos Kemény⁴, Dániel Törőcsik²

Affiliations

¹ Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address: aszegedi@med.unideb.hu.
² Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
³ Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
⁴ Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary; MTA-SZTE Dermatological Research Group, Szeged, Hungary.

PMID: 31564639
DOI: 10.1016/j.it.2019.08.006

Abstract

We propose that acne vulgaris represents a naturally developing, transient inflammatory interaction of adolescent facial skin with its new microbial/chemical milieu (Cutibacterium acnes, sebum), replacing a state of previous childhood skin homeostasis. This concept might explain why acne is characterized by strong regional and age specificity, prevalent occurrence, and resolution.

Keywords: Cutibacterium acnes; acne; homeostasis; inflammation; microbiota; sebum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Homeostasis / immunology*
Host-Pathogen Interactions / immunology*
Humans
Inflammation / immunology
Microbiota / immunology*
Propionibacterium acnes / immunology*