Review of the scientific evidence and technical opinion on noncaloric sweetener consumption in gastrointestinal diseases
Rev Gastroenterol Mex (Engl Ed). 2019 Oct-Dec;84(4):492-510.
doi: 10.1016/j.rgmx.2019.08.001.
Epub 2019 Sep 26.
[Article in
English,
Spanish]
Authors
N Bueno-Hernández
1
, R Vázquez-Frías
2
, A T Abreu Y Abreu
3
, P Almeda-Valdés
4
, L A Barajas-Nava
5
, R I Carmona-Sánchez
6
, J Chávez-Sáenz
7
, A Consuelo-Sánchez
2
, A J Espinosa-Flores
8
, V Hernández-Rosiles
2
, G Hernández-Vez
2
, M E Icaza-Chávez
9
, A Noble-Lugo
10
, A Romo-Romo
4
, A Ruiz-Margaín
11
, M A Valdovinos-Díaz
11
, F E Zárate-Mondragón
12
Affiliations
- 1 Dirección de Investigación, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México. Electronic address: nallely_bh5@yahoo.com.mx.
- 2 Departamento de Gastroenterología y Nutrición, Hospital Infantil de México Federico Gómez, Ciudad de México, México.
- 3 Gastroenterología, Hospital Ángeles Pedregal, Ciudad de México, México.
- 4 Departamento de Endocrinología y Metabolismo Mineral, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
- 5 Unidad de Investigación de Medicina Basada en Evidencia, Hospital Infantil de México Federico Gómez, Ciudad de México, México.
- 6 Unidad de Medicina Ambulatoria Christus Muguerza, San Luis Potosí, México.
- 7 Consulta privada de Gastroenterología Pediátrica, Hospital Puerta de Hierro Andares, Zapopan, Jalisco, México.
- 8 Dirección de Investigación, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México.
- 9 Consulta privada de Gastroenterología, Hospital Star Médica, Mérida, Yucatán, México.
- 10 Departamento de Enseñanza e Investigación, Hospital Español de México, Ciudad de México, México.
- 11 Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
- 12 Servicio de Gastroenterología y Nutrición, Instituto Nacional de Pediatría, Ciudad de México, México.
Abstract
The present review of noncaloric sweeteners (NCSs) by the Asociación Mexicana de Gastroenterología was carried out to analyze and answer some of the most frequent questions and concerns about NCS consumption in patients with gastrointestinal disorders, through a thorough review of the medical literature. A group of gastroenterologists and experts on nutrition, toxicology, microbiology, and endocrinology reviewed and analyzed the published literature on the topic. The working group formulated conclusions, based on the scientific evidence published, to give an opinion with respect to NCS ingestion. Current evidence does not confirm the carcinogenic potential of NCSs. However, the studies analyzed showed that saccharin could have a proinflammatory effect and that polyols can cause gastrointestinal symptoms and manifestations, depending on the dose and type of compound. The ingestion of xylitol, erythritol, sucralose, aspartame, acesulfame K, and saccharin could increase the secretion of the gastrointestinal hormones that regulate intestinal motility, and stevia and its derivatives could have a favorable effect on the percentage of liver fat. Caution should be taken in recommending aspartame consumption in patients with chronic liver disease because it reduces the ratio of branched-chain amino acids to aromatic amino acids. In addition, NCS ingestion could modify the composition of the intestinal microbiota, having an effect on gastrointestinal symptoms and manifestations. It is important to continue conducting causality studies on humans to be able to establish recommendations on NSC consumption.
Keywords:
Cirrhosis; Cirrosis; Edulcorantes no calóricos; Gastrointestinal symptoms; Inflamación; Inflammation; Microbiota; Noncaloric sweeteners; Síntomas gastrointestinales.
Copyright © 2019 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.
MeSH terms
-
Gastrointestinal Diseases / chemically induced*
-
Gastrointestinal Microbiome / drug effects
-
Humans
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Liver Cirrhosis / chemically induced
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Sweetening Agents / adverse effects*
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Sweetening Agents / pharmacology