Antiviral effects of simeprevir on multiple viruses

Zheng Li; Fujia Yao; Guang Xue; Yongfen Xu; Junling Niu; Mengmeng Cui; Hongbin Wang; Shuxian Wu; Ailing Lu; Jin Zhong; Guangxun Meng

doi:10.1016/j.antiviral.2019.104607

Antiviral effects of simeprevir on multiple viruses

Antiviral Res. 2019 Dec:172:104607. doi: 10.1016/j.antiviral.2019.104607. Epub 2019 Sep 26.

Authors

Zheng Li¹, Fujia Yao¹, Guang Xue¹, Yongfen Xu¹, Junling Niu¹, Mengmeng Cui¹, Hongbin Wang¹, Shuxian Wu¹, Ailing Lu², Jin Zhong¹, Guangxun Meng³

Affiliations

¹ CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100039, China.
² CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100039, China; Faculty of Medical Laboratory Science, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
³ CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100039, China. Electronic address: gxmeng@ips.ac.cn.

PMID: 31563599
DOI: 10.1016/j.antiviral.2019.104607

Abstract

Simeprevir was developed as a small molecular drug targeting the NS3/4A protease of hepatitis C virus (HCV). Unexpectedly, our current work discovered that Simeprevir effectively promoted the transcription of IFN-β and ISG15, inhibited the infection of host cells by multiple viruses including Zika virus (ZIKV), Enterovirus A71 (EV-A71), as well as herpes simplex virus type 1 (HSV-1). However, the inhibitory effects of Simeprevir on ZIKV, EV-A71 and HSV-1 were independent from IFN-β and ISG15. This study thus demonstrates that the application of Simeprevir can be extended to other viruses besides HCV.

Keywords: EV-A71; HSV-1; IFN-β; ISG15; Simeprevir; ZIKV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / pharmacology*
Cell Line
Chlorocebus aethiops
Cytokines / metabolism
Enterovirus A, Human / drug effects*
Enterovirus Infections / drug therapy
Hepacivirus / drug effects*
Hepatitis C / drug therapy
Humans
Immunity, Innate
Interferon-beta / metabolism*
Signal Transduction
Simeprevir / pharmacology*
Ubiquitins / metabolism
Vero Cells
Virus Replication / drug effects
Zika Virus / drug effects*
Zika Virus Infection / drug therapy

Substances

Antiviral Agents
Cytokines
Ubiquitins
ISG15 protein, human
Interferon-beta
Simeprevir