The CroCo cross-link converter: a user-centred tool to convert results from cross-linking mass spectrometry experiments

Bioinformatics. 2020 Feb 15;36(4):1296-1297. doi: 10.1093/bioinformatics/btz732.

Abstract

Motivation: A variety of search engines exists for the identification of peptide spectrum matches after cross-linking mass spectrometry experiments. The resulting diversity in output formats complicates data validation and visualization as well as exchange with collaborators, particularly from other research areas.

Results: Here, we present CroCo, a user-friendly standalone executable to convert cross-linking results to a comprehensive spreadsheet format. Using this format, CroCo can be employed to generate input files for a selection of the commonly utilized validation and visualization tools.

Availability and implementation: The source-code is freely available under a GNU general public license at https://github.com/cschmidtlab/croco. The standalone executable is available and documented at https://cschmidtlab.github.io/CroCo.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Mass Spectrometry
  • Peptides*
  • Search Engine
  • Software*

Substances

  • Peptides