Cytochrome P450 Eicosanoid Signaling Pathway in Colorectal Tumorigenesis

Weicang Wang; Katherine Z Sanidad; Guodong Zhang

doi:10.1007/978-3-030-21735-8_11

Cytochrome P450 Eicosanoid Signaling Pathway in Colorectal Tumorigenesis

Adv Exp Med Biol. 2019:1161:115-123. doi: 10.1007/978-3-030-21735-8_11.

Authors

Weicang Wang¹, Katherine Z Sanidad², Guodong Zhang^{3

4}

Affiliations

¹ Department of Food Science, University of Massachusetts, Amherst, MA, USA.
² Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA.
³ Department of Food Science, University of Massachusetts, Amherst, MA, USA. guodongzhang@umass.edu.
⁴ Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, USA. guodongzhang@umass.edu.

PMID: 31562626
DOI: 10.1007/978-3-030-21735-8_11

Abstract

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death in the United States. It is important to discover novel cellular targets which are crucial in the pathogenesis of CRC, which could facilitate development of mechanism-based strategies to reduce the risks of CRC. Emerging studies support that the cytochrome P450 (CYP) monooxygenase/soluble epoxide hydrolase (sEH) pathway and their eicosanoid metabolites play critical roles in colonic inflammation and CRC, and could be therapeutically explored for treating or preventing CRC. Here in this review, we discuss recent studies about the roles of the CYP/sEH eicosanoid pathway in the pathogenesis of colonic inflammation and CRC.

Keywords: Colonic inflammation; Colorectal cancer; Cytochrome P450; Eicosanoids; Soluble epoxide hydrolase.

Publication types

Review

MeSH terms

Carcinogenesis* / metabolism
Colorectal Neoplasms* / physiopathology
Cytochrome P-450 Enzyme System* / metabolism
Eicosanoids* / metabolism
Epoxide Hydrolases / metabolism
Humans
Signal Transduction*

Substances

Eicosanoids
Cytochrome P-450 Enzyme System
Epoxide Hydrolases