Cerebrospinal fluid surrounds and supports the central nervous system, including the ventricles and subarachnoid spaces. Cerebrospinal fluid should be an important source of biomarkers for central nervous system diseases because it is in direct contact with the central nervous system. Many studies are reported on cerebrospinal fluid proteomics, highlighting many recent progresses. Here, we review recent advances in proteomics technology and clinical application of cerebrospinal fluid.
脑脊液 (CSF) 围绕并支持中枢神经系统 (CNS)，包括脑室和蛛网膜下腔，由于脑脊液与中枢神经系统直接接触，所以其是寻找中枢神经系统疾病生物标记物的重要来源。国内外学者开展了大量CSF 蛋白质组学的研究工作，并取得了较大进展。文中综述了近年来CSF 蛋白质组学技术及临床应用研究进展。.
Keywords: cerebrospinal fluid; clinical application; diagnostic markers; mass spectrometry; proteomics.