Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience

Haruhiro Inoue; Hironari Shiwaku; Yasutoshi Kobayashi; Philip W Y Chiu; Robert H Hawes; Horst Neuhaus; Guido Costamagna; Stavros N Stavropoulos; Norio Fukami; Stefan Seewald; Manabu Onimaru; Hitomi Minami; Shinwa Tanaka; Yuto Shimamura; Esperanza Grace Santi; Kevin Grimes; Hisao Tajiri

doi:10.1007/s10388-019-00689-6

Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience

Esophagus. 2020 Jan;17(1):3-10. doi: 10.1007/s10388-019-00689-6. Epub 2019 Sep 26.

Authors

Haruhiro Inoue¹, Hironari Shiwaku², Yasutoshi Kobayashi³, Philip W Y Chiu⁴, Robert H Hawes⁵, Horst Neuhaus⁶, Guido Costamagna⁷, Stavros N Stavropoulos⁸, Norio Fukami⁹, Stefan Seewald¹⁰, Manabu Onimaru¹¹, Hitomi Minami¹², Shinwa Tanaka¹³, Yuto Shimamura¹¹, Esperanza Grace Santi¹⁴, Kevin Grimes¹⁵, Hisao Tajiri¹⁶

Affiliations

¹ Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Toyosu 5-1-38, Koto-Ku, Tokyo, 135-8577, Japan. haruinoue777@yahoo.co.jp.
² Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7-45-1, Nanakuma, Jyonan-ku, Fukuoka, 814-0180, Japan.
³ Department of Gastroenterology and Hepatology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
⁴ The Institute of Digestive Disease, Faculty of Medicine of the Chinese University of Hong Kong, Hong Kong, China.
⁵ Center for Interventional Endoscopy, Florida Hospital Orlando, Orlando, Florida, USA.
⁶ Department of Internal Medicine, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany.
⁷ Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, Rome, Italy.
⁸ Division of Gastroenterology, Hepatology, and Nutrition, NYU-Winthrop Hospital, New York, USA.
⁹ Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
¹⁰ Centre of Gastroenterology, Klinik Hirslanden, Zurich, Switzerland.
¹¹ Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Toyosu 5-1-38, Koto-Ku, Tokyo, 135-8577, Japan.
¹² Department of Gastroenterology and Hepatology, Nagasaki University, Nagasaki, Japan.
¹³ Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan.
¹⁴ Section of Gastroenterology and Digestive Endoscopy, De La Salle University Medical Center, Dasmarinas City, Philippines.
¹⁵ Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
¹⁶ Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo, Japan.

Abstract

It has been 10 years since peroral endoscopic myotomy (POEM) was reported for the first time, and POEM has currently become the standard treatment for achalasia and related disorders globally because it is less invasive and has a higher curative effect than conventional therapeutic methods. However, there are limited studies comparing the long-term outcomes of POEM with those of conventional therapeutic methods, particularly in the occurrence of gastroesophageal reflux disease (GERD) after therapy. With this background, we held a consensus meeting to discuss the pathophysiology and management of GERD after POEM based on published papers and experiences of each expert and to discuss the prevention of GERD and dealing with anti-acid drug refractory GERD. This meeting was held on April 27, 2018 in Tokyo to establish statements and finalize the recommendations using the modified Delphi method. This manuscript presents eight statements regarding GERD after POEM.

Keywords: Achalasia; GERD; Myotomy.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Consensus
Consensus Development Conferences as Topic
Delphi Technique
Endoscopy, Digestive System / methods
Endoscopy, Digestive System / trends
Esophageal Achalasia* / complications
Esophageal Achalasia* / surgery
Gastroesophageal Reflux* / diagnosis
Gastroesophageal Reflux* / etiology
Gastroesophageal Reflux* / physiopathology
Gastroesophageal Reflux* / prevention & control
Humans
Myotomy* / adverse effects
Myotomy* / methods
Natural Orifice Endoscopic Surgery* / methods
Postoperative Complications / physiopathology
Tokyo / epidemiology