Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

Poh Yen Khor; Mohd Fadhlizil Fasihi Mohd Aluwi; Kamal Rullah; Kok Wai Lam

doi:10.1016/j.ejmech.2019.111704

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

Eur J Med Chem. 2019 Dec 1:183:111704. doi: 10.1016/j.ejmech.2019.111704. Epub 2019 Sep 16.

Authors

Poh Yen Khor¹, Mohd Fadhlizil Fasihi Mohd Aluwi², Kamal Rullah³, Kok Wai Lam⁴

Affiliations

¹ Faculty Pharmacy and Health Sciences, Universiti Kuala Lumpur, Royal College of Medicine Perak, 3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia; Drugs and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia. Electronic address: pykhor@unikl.edu.my.
² Faculty of Industrial Science & Technology, Universiti Malaysia Pahang Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia. Electronic address: fasihi@ump.edu.my.
³ Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, 25200, Kuantan, Pahang, Malaysia. Electronic address: kamalrullah@iium.edu.my.
⁴ Drugs and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia. Electronic address: david_lam@ukm.edu.my.

PMID: 31557608
DOI: 10.1016/j.ejmech.2019.111704

Abstract

Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine.

Keywords: Asymmetric curcumin; Bioactivity; Diketone; Monoketone; Synthesis.

Publication types

Review

MeSH terms

Acute Lung Injury / drug therapy
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Carbonic Anhydrase Inhibitors / chemical synthesis
Carbonic Anhydrase Inhibitors / chemistry
Carbonic Anhydrase Inhibitors / pharmacology*
Carbonic Anhydrases / metabolism
Curcumin / chemical synthesis
Curcumin / chemistry
Curcumin / pharmacology*
Humans
Molecular Structure
Neoplasms / drug therapy*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Antineoplastic Agents
Carbonic Anhydrase Inhibitors
Carbonic Anhydrases
Curcumin